Vaginal dryness

Vaginal atrophy (vaginal dryness) is the thickening of the vaginal wall, which causes the vagina to lose its elasticity and the internal epithelium of the vagina becomes drier.

The resultant burning, itchy or inflamed sensation in the vagina, together with painful sexual intercourse are all signs of vaginal dryness.

Unfortunately, vaginal dryness affects many women and has to be taken seriously. It is often a constant feeling of vaginal discomfort and a decrease in libido. The negative effects of painful sex put even the most harmonious relationships to the test. Due to the intimate nature of the subject, many women choose not to talk about this discomfort and only a minority of them seeks medical attention. However, it is important to know that solutions exist for the treatment of vaginal dryness, no one has to accept this condition and suffer in silence! Furthermore, menopause does not mean the end of sexual intimacy.

Science behind the product

The JUVIA vaginal gel has been developed to relieve the unpleasant symptoms associated with vaginal dryness. The scientific foundation of the development is based on several decades of basic and clinical research by Prof. Dr. Peter Takacs. This product is protected by a registered patent.*

This patented vaginal gel helps to restore the integrity of the vaginal wall and vaginal mucosa and improves vaginal health. Our goal is to provide an alternative to estrogen hormone therapies in order to alleviate the symptoms of vaginal atrophy.

A number of peer reviewed scientific publication has been published about the effectiveness and safety of JUVIA, including:

  1. Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study (Journal of Menopausal Medicine 2019;25:63-68)
  2. Biocompatibility and zinc release testing of a zinc-containing vaginal gel (Menopause: The Journal of The North American Menopause Society, 2019 Vol. 27, No. 2)
  3. Novel zinc containing vaginal moisturizer gel (JUVIA) improves postmenopausal vulvovaginal symptoms (poster presented at IUGA 2018 Annual Meeting in Vienna)

*The scientific foundation for product development has been summarized under the U.S. Patent No. 9,375,450 entitled VAGINAL TISSUE REJUVENATION COMPOSITIONS AND METHODS. Filed: June 28, 2016, International Publication Nos. US2012 / 046072, and WIPO Patent WO / 2013 / 012614A1

JUVIA clinical research

At the University of Debrecen, Hungary a six months clinical trial was conducted in 2018 to determine the safety and effectiveness of treatment with Juvia vaginal gel.

Over 60% of the paticipating women said that the moisturizing effect lasted for more than a week. This means that a single tube of JUVIA can treat vaginal dryness from up to four to five months.

The Vaginal Health Index (VHI) is a system used to evaluate vaginal elasticity, fluid volume, pH, epithelial integrity, and moisture on a scale of 1 to 5. One of the most important results of the clinical research was that all these factors improved significantly after using Juvia and consequently Juvia positively contributed to the quality of life of participants.

Research results were published in the Journal of Menopausal Medicine in April 2019. The article is available here.

The following video summarizes the results of a patient satisfaction survey conducted after the clinical trial.

To learn more about this clinical research, please download our summary: juvia_clinical_trial_summary.pdf

Scientific basis for vaginal zinc replacement

Zinc is one of the most important essential minerals in the human body. In addition numerous clinical studies testify that zinc plays a crucial role in the treatment of vaginal dryness.

Scientific animal experiments

The vagina of female mice held on a zinc deficient diet resembles an atrophic postmenopausal vagina corresponding to menopausal changes. [1]

The vagina of mice suffering from zinc deficiency is similar to that of ovariectomized (OVX) animals [2]

The plasma concentration of zinc in Buffalos with antepartum vaginal prolapse is significantly lower compared to normal pregnant Buffalos during the period 9 months to term. [3]

Rat studies showed that treatment of zinc deficiencies improves wound healing of colon anastomosis due to increased collagen type I/III ratio. Increased collagen type I/III ratio in rats also showed improved vaginal healing. [4]

Gynecology research

Zinc tissue levels in the human uterus are the lowest during menopause and a deficiency in Zn may contribute to atrophic changes. [5]

In human vaginal smooth muscle cell culture, zinc has a beneficial effect on the production of muscle-derived extracellular components at 20 µM tissue level, thereby increasing collagen and elastin production and smooth muscle [6].

Taneja S. K., Kaur R.: Pathology of ovary, uterus, vagina and gonadotrophs of female mice fed on Zn-deficient diet; Indian Journal of Experimental Biology, Vol. 28., Nov 1990, pp 1058-1065
P. Takacs et al. The Effects of PPARD Agonist and Zinc on Ovariectomized Rats’ Vagina. Female Pelvic Med Reconstr Surg 2013;19: 126-131.
M.A. Kelkar, S.K. Khar and M. Mandakhot: Studies on antepartum prolapse of the vagina in buffalo- plasma trace element concentration; Arch. exper. Vet. med., Leipzig 43 (1989), 315-318
P. Takacs et al. The Effects of PPARD Agonist and Zinc on Ovariectomized Rats’ Vagina. Female Pelvic Med Reconstr Surg 2013;19: 126-131.
Isabelle Bureau, Richard A. Anderson, Josaine Arnaud, Yves Raysiguier, Alain E. Favier and Anne-Marie Roussel: Trace mineral status in post menopausal women: impact of hormonal replacement therapy; J. Trace Elem. Med. Biol. Vol. 16. p 9-13. (2002)
P. Takacs et al. Effects of PPAR-delta agonist and zinc on vaginal smooth muscle cells collagen and tropoelastin production. Int Urogynecol J (2012) 23:1775–1779.